Sodium current kinetics in intact rat papillary muscle: measurements with the loose-patch-clamp technique.
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چکیده
منابع مشابه
Intact Heart Loose Patch Photolysis Reveals Ionic Current Kinetics During Ventricular Action Potentials.
RATIONALE Assessing the underlying ionic currents during a triggered action potential (AP) in intact perfused hearts offers the opportunity to link molecular mechanisms with pathophysiological problems in cardiovascular research. The developed loose patch photolysis technique can provide striking new insights into cardiac function at the whole heart level during health and disease. OBJECTIVE ...
متن کاملNEW METHODS IN CARDIOVASCULAR BIOLOGY Intact Heart Loose Patch Photolysis Reveals Ionic Current Kinetics During Ventricular Action Potentials
Rationale: Assessing the underlying ionic currents during a triggered action potential (AP) in intact perfused hearts offers the opportunity to link molecular mechanisms with pathophysiological problems in cardiovascular research. The developed Loose Patch Photolysis (LPP) technique can provide striking new insights into cardiac function at the whole heart level during health and disease. Objec...
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embryonic stem cells are capable of differentiating to variety of cell tissues including cardiomyocytes. this developmental change is accompanied with a great deal of ion channel expression and functions. mouse stem cell derived cardiomyocytes were prepared and separated to yield isolated single cell suspension for cell current recording. in the present study some properties of the k + -current...
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Upon ejaculation, mammalian spermatozoa have to undergo a sequence of physiological transformations within the female reproductive tract that will allow them to reach and fertilize the egg. These include initiation of motility, hyperactivation of motility and perhaps chemotaxis toward the egg, and culminate in the acrosome reaction that permits sperm to penetrate the protective vestments of the...
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One of the basic cellular functions of virtually every cell type is the exocytotic release of molecules synthesized, stored and packaged into intracellular vesicles or granules. Over decades much effort has been concentrated on elucidating the chain of events leading to exocytosis. Unfortunately, the nature of the process that ultimately induces membrane fusion is not known, nor has it been est...
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ژورنال
عنوان ژورنال: The Journal of Physiology
سال: 1988
ISSN: 0022-3751
DOI: 10.1113/jphysiol.1988.sp017376